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Down's Syndrome, also known as Trisomy 21, is primarily caused by genetic factors. Specifically, it occurs due to the presence of an extra 21st chromosome, which leads to the characteristic features and developmental challenges associated with the condition. The extra genetic material is a result of nondisjunction, an error in cell division during the formation of eggs or sperm. This genetic abnormality has significant implications for physical development, cognitive function, and overall health.

While environmental factors can influence the presentation of symptoms and quality of life for individuals with Down's Syndrome, they do not cause the condition itself. Psychological factors, while relevant for understanding the experiences and emotions of individuals with Down's Syndrome, also do not contribute to its genetic origins. Infectious causes are unrelated to Down's Syndrome, as the condition is not caused by pathogens or viruses. Thus, genetic causation is a fundamental aspect of Down's Syndrome, distinguishing it from other types of conditions that might arise from environmental, psychological, or infectious influences.